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Letrozole, a generic drug, is relatively inexpensive. Thirty pills cost around $56, similar to the cost of clomiphene, Legro said. "This is an affordable form of infertility treatment," he said.
The overall ovulation rate was higher with letrozole than with clomiphene 62 percent compared to 48 percent.
Penn State University's College of Medicine in Hershey, Penn.
Also, women taking letrozole had fewer twin pregnancies, compared with those taking clomiphene about 3 percent versus 7 percent, the study found.
Whether letrozole will cause more birth defects than other drugs isn't known, Legro said. "We will need other studies to show that the rates of birth defects are actually low lower than we would expect in an infertile population," he said.
Breast Cancer Drug May Help Women Fight a Leading Cause of Infertility
Clomiphene was associated with hot flashes, while some women using letrozole reported fatigue and dizziness. For both drugs, birth defects were rare and rates were similar. They were comparable with those seen in studies of women who conceive without treatment, Legro said.
in better ovulation, conception and birth rates.
Currently, doctors typically prescribe clomiphine (Clomid) to boost fertility for women with polycystic ovary syndrome. However, this new study suggests the drug letrozole (Femara) results Nike Vapormax Red Bronze
Polycystic ovary syndrome the most common cause of female infertility in the United States causes higher than normal levels of the male hormone androgen, infrequent periods and small cysts on the ovaries. It affects 5 to 10 percent of reproductive age women, according to background information in the study.
"We found a simple and comparatively safe and vastly more effective treatment for [polycystic ovary syndrome]," said lead researcher Dr. Richard Legro, a professor of obstetrics and gynecology at Nike Air Vapormax Flyknit Bordeaux
WEDNESDAY, July 9, 2014 (HealthDay News) Women with polycystic ovary syndrome have a better chance of getting pregnant if they take a breast cancer drug instead of the currently preferred medication, a new study suggests.
Hershlag said he prescribes both letrozole and clomiphene for patients. "The decision to use one or the Nike Air Vapormax Red Black other depends on several factors, including insurance coverage and cost," he said.
Clomiphine, which works by stimulating ovulation, has been the standard treatment for years, but has a high rate of multiple births, Legro said.
For the study, Legro's team randomly assigned 750 women with polycystic ovary syndrome to take clomiphene or letrozole. The drugs were given in five menstrual cycles with the dosage increased with each cycle.
Letrozole, a treatment for breast cancer in postmenopausal women, works by blocking estrogen production, tricking the ovaries into producing more of the hormone, he explained. National Institutes of Health, was published July 10 in the New England Nike Vapormax Pure White
Journal of Medicine.
"Clomiphine may be trumped," Legro said. "To see a 40 percent improvement in birth rate is a huge difference."
Researchers found that almost 28 percent of the women taking letrozole had babies after five cycles, compared with about 19 percent of those taking clomiphene.
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