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Both studies included analysis of five years of treatment over a Nike Vapormax Chukka Boots
The study is published in the July 10 issue of the New England Journal of Medicine. The findings were also presented at the American Society of Clinical Oncology annual meeting in June.
But, women taking Aromasin experienced more osteoporosis a condition caused by Nike Vapormax Womens Black thinned bones. The rate of osteoporosis was 13.2 percent in the Aromasin group versus 6.4 percent in the tamoxifen group. Women taking Aromasin also reported more fractures, vaginal dryness, decreased sex drive and painful sexual intercourse. But, women on tamoxifen had more blood clots, hot flashes, sweating and urinary incontinence, according to the study.
That's why aromatase inhibitors have traditionally been used in postmenopausal women, and have been shown to work Nike Vapormax Custom
And both drugs came with significant side effects. For Aromasin, those side effects included osteoporosis, vaginal dryness and decreased sex drive, among others. For tamoxifen, side effects included blood clots, hot flashes and urinary incontinence, according to the study.
"It's another option," said Dr. Joanne Mortimer, director of women's cancer programs at the City of Hope Comprehensive Cancer Center in Duarte, Calif. She reviewed the findings and said that the aromatase inhibitor would be a trade off. "Compared to aromatase inhibitors, the quality of life is better with tamoxifen for premenopausal women," she said. National Cancer Institute, Pfizer (which makes Aromasin), Ipsen (makers of an ovarian suppression drug) and the International Breast Cancer Study Group.
Compared to tamoxifen, Aromasin reduced the risk of breast cancer recurrence by 34 percent.
Dr. Hope Rugo, clinical professor of medicine and director of the breast oncology and clinical trials program at the Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, wrote an editorial to accompany the study. The aromatase inhibitor led to more sexual problems, osteoporosis, muscle and joint symptoms, she said. These "may be more noxious to young women than the hot flushes experienced with tamoxifen," she wrote.
better for them than tamoxifen. Tamoxifen is typically used in breast cancer patients who have not yet gone through menopause because it can block estrogen that's circulating in the body.
WEDNESDAY, July 9, 2014 (HealthDay News) The drug exemestane worked slightly better than the drug tamoxifen at preventing a recurrence of breast cancer in certain premenopausal women, according to a new study.
Some breast cancers dubbed hormone receptor positive are fueled by the hormone estrogen. Tamoxifen works by blocking estrogen from getting into cancer Nike Air Vapormax Glacier Blue
median follow up of more than 5.5 years.
The study researchers combined the results of two phase 3 clinical trials, known as the Tamoxifen and Exemestane Trial (TEXT) and the Suppression of Ovarian Function Trial (SOFT).
Almost 93 percent of women on exemestane (Aromasin) remained free of breast cancer after five years, compared to about 89 percent of the women on tamoxifen. That's according to the study of nearly 4,700 women with breast cancer who all had their ovarian function suppressed.
Now, the new study suggests that aromatase inhibitors may be an option for premenopausal women, although not everyone thinks the new research will greatly change practice.
cells. Aromasin part of a class of drugs known as aromatase inhibitors works by stopping other hormones from changing into estrogen, according to the American Cancer Society. Aromatase inhibitors are only helpful if the ovaries aren't still producing estrogen.
Breast Cancer Drug Aromasin May Be Option for Some Premenopausal Women
All of the women in the studies had hormone receptor positive breast cancer. They also all had their ovarian function suppressed to further thwart cancer growth.
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